Satellite Event

Monday, June 23rd 2025 full day, and Tuesdat, June 24^th 2025 in the morning
Satellite Event of the XVIII International Congress of the Spanish Biophysical Society

14:00-15:00

Registration and collection of documentation at the lobby of the classrooms building (QC) of the Faculty of Chemical Sciences UCM.

15:00

Opening Ceremony, Main Hall Alfredo Pérez Rubalcaba.

Greeting and welcome by Federico Morán Abad, Professor, SBE member, and Director of the Foundation for Knowledge Madri+d, Lucía de Juan Ferré, Vice Rector of Research and Transfer of the Complutense University, and Mayte Villalba Díaz, Dean of the Faculty of Chemical Sciences of the UCM.

Introduction by José María Valpuesta, president of the SBE.

15:30

Plenary Lecture (I), Main Hall Alfredo Pérez Rubalcaba.

Chair: Álvaro Martínez-del-Pozo, Professor, Department of Biochemistry and Molecular Biology, Faculty of Chemical Sciences, Complutense University, Madrid..

Lecturer: Jonathan Heddle, Centre for Programmable Biological Matter, Durham University, UK.

Title: Programmable Biological Matter.

16:30-18:30

Two parallel sessions.

Session 1

(Classroom QC13): Cell and tissue biophysics. Mechanobiology.

Chairs: Elías Herrero Galán, Molecular Mechanics of The Cardiovascular System Laboratory, Assistant Researcher at Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid.

Ion Andreu, Instituto de Biofísica de Leioa, Vizcaya.

Two talks of about 25-30 min:

Daniel García González, Multibiostructures Lab, Universidad Carlos III de Madrid.

Title: Soft magneto-responsive biological substrates: new avenues for mechanobiology exploration.

Michael Krieg, Neurophotonics and Mechanical Systems Biology Group, Instituto de Ciencias Fotónicas (ICFO), Castelldefels, Barcelona.

Title: Dissecting the mechanical heterogeneity of intracellular organelles and their contribution to development and disease.

Five short talks of 10 minutes long:

1. Roberto Silva-Rojas, Centro Nacional de Investigaciones Cardiovasculares (CNIC).
   Title: A mechanical knock-out system uncovers that loss of titin tension triggers muscle disease.

2. Marina Garrido-Casado, CSIC-Centro de investigación del cáncer Salamanca.
   Title: Citron kinase controls retraction-protrusion balance in migrating cells.

3. Agata Bak, Centro Nacional de Investigaciones Cardiovasculares (CNIC).
   Title: Intramolecular crosslinking glycation in titin stiffens cardiomyocytes.

4. Jorge González-Rico Iriarte, Universidad Carlos III de Madrid.
   Title: Magneto-mechanical actuation guides fibroblast-ECM interactions and remodeling on fibrin-based magneto-active hydrogels.

5. Blanca González Bermúdez, Universidad Politécnica de Madrid.
   Title: Simultaneous characterization of viscoelastic and electrical properties of cells using constriction-based impedance flow cytometry.

Session 2

(Classroom QC23): Disordered proteins. Liquid-liquid phase separation and aggregation.

Chairs: Nunilo Cremades Casasín, Associate Professor at Department of Biochemistry and Molecular Biology, Faculty of Sciences, NeuroBioSys – Molecular Neurobiology and Systems Biology Group, Universidad de Zaragoza.

Germán Rivas Caballero, Professor, leader of Biochemistry of bacterial division systems group, CIB-Margarita Salas, CSIC, Madrid.

Two talks of about 25-30 min:

Benedetta Bolognesi, Group leader, Protein phase transitions in health and disease, Institute for Bioengineering of Catalonia (IBEC), Barcelona.

Title: Deep mutagenesis to interpret variant effects and extract mechanistic insights into amyloid transition states.

Javier Oroz, Assistant Professor, Protein NMR Group, Blas Cabrera Institute for Physical Chemistry-CSIC, Madrid.

Title: Metamorphic structures priming alternative aggregates in human diseases.

Two short talks of 20 minutes long:

1. Nisha Pawar Chauhan, Institute for Bioengineering of Catalonia (IBEC), Barcelona.
   Title: Unlocking the Dynamics of Intrinsically disordered protein with Liquid Transmission Electron Microscopy and Flicker Spectroscopy.

2. Salvador Ventura, Universitat Autònoma de Barcelona.
   Title: A Structure-Based Approach to Tackle Protein Aggregation in Parkinson’s Disease.

Two flash talks of 10 minutes long:

1. Marta Sobrinos-Sanguino, Centro de Investigaciones Biológicas Margarita Salas (CSIC), Madrid.
   Title: Bacterial cell division regulator MatP forms dynamic biomolecular condensates and interacts with the essential division protein FtsZ.

2. David Polanco, Institute for Biocomputation and Physics of Complex Systems (BIFI), University of Zaragoza.
   Title: Electrostatic network stabilization and protein arrest of tau and alpha synuclein in the context of protein phase separation.

18:30-20:30

Welcome cocktail at the garden of the Faculty of Chemistry.

9:00-10:00

Continuing Registration and collection of documentation at the lobby of the classrooms building (QC) of the Faculty of Chemical Sciences UCM.

9:00-11:00

Two parallel sessions.

Session 3

(Classroom QC13): Protein structure, integrative structural biology, dynamics and function.

Chairs: Douglas V. Laurents, Senior Scientist, Protein NMR Group, Institute of Physical Chemistry Blas Cabrera, CSIC, Madrid.

Jorge Cuéllar, Tenured Scientist, Department of Macromolecular Structures, Centro Nacional de Biotecnología, CSIC, Madrid.

Two talks of about 25-30 min:

Sara García-Linares, Associate professor, Department of Biochemistry and Molecular Biology, Faculty of Chemical Sciences, Complutense University, Madrid.

Title: Design of nanoreactors for microplastic depolymerization based on pore-forming proteins.

Marina Serna, National Cancer Research Center (CNIO), Madrid, Spain.

Title: Microtubule assembly in mitotic spindle formation: Insights from cryo-EM.

Seven short talks of 7 minutes long:

1. Marina Mínguez-Toral, Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC).
   Title: Comprehensive MD simulations for conformational functional analysis: case for multidomain and transmembrane receptor dimers.

2. Irene Ginés, Universidad de Zaragoza.
   Title: Recognizing Tn and STn Epitopes in Protein Context.

3. Rafael Tapia-Rojo, King’s College London.
   Title: Mechanical Force Activates FAK Phosphorylation to Block Paxillin Binding.

4. Jimena Muntaner, CNB-CSIC.
   Title: Structural characterization of a complex involved in chaperone-assisted UPS degradation.

5. Juan Hermoso, Institute of Physical Chemistry Blas Cabrera (CSIC).
   Title: Reversing β-lactam resistance in Methicillin-resistant Staphylococcus aureus.

6. Jordi Pujols, Universitat Autònoma de Barcelona.
   Title: MIA40 bypasses the folding constraints imposed by TRIAP1 function.

7. Sonia Huecas, CIB Margarita Salas, CSIC.
   Title: Cryo-EM studies on RNA polymerase III transcriptional pausing.

Session 4

(Classroom QC23): Biophysics of nucleic acids.

Chairs: Carolina Carrasco Pulido, Research Scientist in Department of Macromolecular Structures, Centro Nacional de Biotecnología, CSIC, Madrid..

María Mañosas, Associate Professor in Condensed Matter Physics at the University of Barcelona (UB).

Two talks of about 25-30 min:

Julene Madariaga-Marcos, Postdoctoral Researcher, Leipzig University, Germany.

Title: Investigating target specificity by CRISPR-Cas9 with ultrafast twist measurements.

Federica Battistini, Associate Professor at Institute for Research in Biomedicine (IRB), Barcelona.

Title: hexABC, a DNA conformational study at the hexamer level.

Three short talks of 12 minutes long:

1. Sara De Bragança, Centro Nacional de Biotecnología (CNB-CSIC).
   Title: The Role of Ku Threading in APLF-Mediated DNA End Bridging.

2. Alejandro Colchero, Universidad de Barcelona.
   Title: Origin of translocation time dispersion in DNA translocation through nanopores.

3. Xavier Viader Godoy, Universitat de Barcelona.
   Title: Characterization of polymerase mutants from Directed Evolution experiments using Magnetic Tweezers.

Three short flash talks of 5 minutes long:

1. Francisco J. Cao García, Universidad Complutense de Madrid.
   Title: Single-stranded DNA-binding protein kinetics: theory and experiments.

2. Michael Stich, Universidad Rey Juan Carlos.
   Title: Reconstruction, validation and Molecular Dynamics simulation of an all-atom model of an RNA bacteriophage with complete genome.

3. Carlos Gonzalez Ibañez, Instituto de Química Física Blas Cabrera – CSIC.
   Title: Unraveling the Structure and Dynamics of Non-canonical DNA Motifs.

11:00-11:30

Coffee break (at the same halls of the first and second floors of the classrooms building where posters will be posted)

11:30-12:30

Plenary Lecture (II), Main Hall Alfredo Pérez Rubalcaba.

Chair: Sara García-Linares, Associate professor, Department of Biochemistry and Molecular Biology, Faculty of Chemical Sciences, Complutense University, Madrid.

Lecturer: Beatrix Suess, Synthetic RNA biology, Department of Biology, TU Darmstadt, Denmark.

Title: Synthetic riboswitches.

12:30-13:00

Sponsor presentation, Main Hall Alfredo Pérez Rubalcaba. Two 10-15 minutes long presentations:

ThermoFisher.
Dhirendra Singh (Ph.D), Product Specialist TEM- Life Sciences, TherrmoFisher Scientific, Eindhoven, Netherlands

Title: Introducing Krios 5 Cryo-TEM- Enhanced throughput for SPA and a contamination free workflow for Cryo-ET

Fernando Gil, ALBA Synchrotron, Cerdanyola del Vallès, Barcelona.

Title: Advanced solutions for macromolecular structural biology at ALBA Synchrotron.

13:00-14:30

Lunch at the self-service cafeteria of the Faculty of Chemical Sciences.

14:30-16:30

Poster session I (at the halls of the first and second floors of the classrooms building).

16:00-16:30

Coffee break (at the same halls of the first and second floors of the classrooms building where posters will be posted).

16:30-18:30

Two parallel sessions.

Session 5

(Classroom QC13): Applied biophysics for industry, biotechnology, health and green transition.

Chairs: Sara Hernández Mejías, Research Scientist, group leader of the Bio-engineered nanophotonics, IMDEA Nanociencia, Madrid.

Beatriz Ibarra-Molero, Professor, Department of Physico-Chemistry, Universidad de Granada.

Two talks of about 25-30 min:

Starla Glover, Assistant professor, Department of Chemistry – Ångström Laboratory, University of Uppsala, Sweden.

Title: Well-defined de novo proteins to as a platform to study proton coupled-electron transfer from redox active amino acids and catalysis for hydrogen production

Tino Krell, Research Professor, Estación Experimental del Zaidín (CSIC), Granada.

Title: The combined use of thermal shift assays, structural biology and isothermal titration calorimetry to identify signals that stimulate bacterial receptors.

Three short talks of 15 minutes long:

1. Asier García González, IMDEA Nanociencia.
   Title: Understanding the impact of amino acid networks on protein-based artificial photosystems.

2. María José Sánchez Barrena, Instituto de química física Blas Cabrera – CSIC.
   Title: Development of chemical, biophysical and crystallographic workflows that enable rapid and cost-effective drug discovery.

3. Aitor Manteca, CICBiomagune.
   Title: Integrating Droplet Microfluidics and Fluorescence Polarization for High-Throughput Epitope Discovery.

Three short flash talks of 5 minutes long:

1. Gonzalo Pérez Serrano, IMDEA Nanociencia.
   Title: Designing model photosystem for tracking protein dynamics in chromophore´s light harvesting properties.
2. Paula Cinca Fernando, Institute for Biocomputation and Physics of Complex Systems, University of Zaragoza.
   Title: Structural and functional insight into the aryl-alcohol oxidase family.

Session 6

(Classroom QC23): Computational biophysics. Simulations, artificial intelligence, machine learning and design.

Chair: Chantal Valeriani, Associate Professor, Department of Structure of Matter, Thermal and Electronic Physics, Faculty of Physical Sciences, Complutense University of Madrid, Madrid.

Jordi García-Ojalvo, Dynamical Systems Biology lab, Systems Bioengineering, Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona.

Two talks of about 25-30 min:

Beatriz Seoane Bartolomé, Dynamics of disordered systems, Department of Theoretical Physics, Faculty of Physics, Complutense University of Madrid.

Title: Beyond Maximum Entropy: Interpretable Modeling with Restricted Boltzmann Machines.

Mario Castro Ponce, Departamento de Telemática y Computación, Escuela Técnica Superior de Ingeniería (ICAI), Universidad Pontifica de Comillas, Madrid.

Title: B cell receptors and free antibodies have different antigen-binding kinetics.

Six short talks of 10 minutes long:

1. Jacobo Aguirre, Centro de Astrobiología CSIC-INTA.
   Title: Polymerization and replication of primordial RNA explained by clay-water interface dynamics in early Earth.

2. Valeria Zoni, Universidade de Vigo.
   Title: The effect of drug resistance mutations on the folding stability and binding affinity of the HIV-1 integrase.

3. Jaime Tejedor Reyes, Instituto de Ciencias Materiales de Madrid – CSIC.
   Title: High-Throughput Nanorheology of Living Cells Powered by Supervised Machine Learning.

4. Bohan Zhang, Universidad Complutense de Madrid.
   Title: Mechanical properties of bacterial biofilms.

5. Zahra Saeidikia, Institute of Bioengineering of Catalonia.
   Title: Molecular Dynamics Simulations of Amyloid Beta Assembly combined with Real-Time Imaging via Liquid-Phase TEM.

6. Giancarlo Franzese, Universitat de Barcelona.
   Title: Multiscale simulations, machine learning, experiments, theory, and design for the protein-nanoparticle coronas.

9:00-11:00

Two parallel sessions.

Session 7

(Classroom QC13): Synthetic biophysics: self-organized and biomimetic systems.

Chairs: Aitziber López Cortajarena, Professor, Biomolecular Nanotechnology Laboratory, CICbiomaGUNE, Parque Científico y Tecnológico de Gipuzkoa, Donostia/San Sebastián.

Roger Castells-Graells, Junior Group Leader, CNIO, Madrid.

Two talks of about 25-30 min:

Beatriu Escuder, Institute of Advanced Materials, Organic Chemistry, Department of Inorganic and Organic Chemistry, Universitat Jaume I (INAM – UJI).

Title: Self-assembling short peptides as protein mimetics.

Silvia Hernández Aínsa, Instituto de Nanociencia y Materiales de Aragón (INMA).

Title: Synthetic Nanostructures via Nucleic-Acid Self-Assembly: From Therapeutics to Biomimetics.

Six short talks of 8 min.

1. Paula Isla Gangoiti, CICBiomagune.
   Title: Engineering Gold-based Artificial Metalloenzymes Based on CTPR Proteins for Catalytic Applications and Immobilization in Solid Materials.

2. Pavel Bashkirov, Research Institute for Systems Biology and Medicine.
   Title: Biomimetic soft-elastic nanotubes for single-molecule sensing and functional proteomics.

3. Laura Perez-Chirinos, Spanish National Cancer Research Centre (CNIO).
   Title: The Protein NanoHedra database (PNHdb): An innovative database for the design of novel symmetric protein architectures via deep learning methods.

4. Claudia Flórez Echavarría, IMDEA Nanociencia.
   Title: The relevance of amino acid-chromophore interactions in protein conformational changes.

5. Miguel Ángel Robles-Ramos, Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC).
   Title: Modulation of bacterial cell division biomolecular condensates by agonists and antagonists of ring formation.

6. Pablo San Segundo-Acosta, Max Planck Institute of Biophysics.
   Title: The cryo-EM structures of the Elp-Hdr and Mvh-Hdr-Fmd supercomplexes confirm an altered electron flow in Methanothermobacter marburgensis under nickel limitation.

Session 8

(Classroom QC23): Membrane and membrane proteins.

Chairs: Teresa Giráldez, Department of Basic Medical Sciences, Institute of Biomedical Technologies, University of La Laguna, Canary Islands.

Carlo Manzo, Associate Professor, Department of Biosciences, FCTE, Universitat de Vic – Universitat Central de Catalunya.

Two talks of about 25-30 min:

Tania López Hernández, Ramón y Cajal Researcher, Department of Physiological Sciences, University of Barcelona

Title: Endocytosis under stress: The yin and yang of NHE7-mediated ion homeostasis in cellular balance.

Alex Peralvarez-Marin, Biophysics Unit, Biochemistry and Molecular Biology Department, Institute of Neuroscience, Universitat Autonoma de Barcelona

Title: Mapping Bioactive Lipid Binding Sites in Ion Channels through Computational Lipid Fingerprinting.

Five short talks of 10 minutes long:

1. Ivan López Montero, Universidad Complutense de Madrid.
   Title: Fusion of giant vesicles mediated by the mitochondrial fusion protein Mfn2.

2. Daniel Muñoz Reyes, Institute for Biocomputation and Physics of Complex Systems (BIFI).
   Title: Targeting the Neuronal Calcium Sensor 1 to modulate dopamine D2 receptor function: A structure-based drug repurposing approach.

3. María Navarro Pérez, Universitat de Barcelona.
   Title: Functional consequences of Kv1.3 palmitoylation at the immunological synapse.

4. Igor Tascon, Instituto Biofisika.
   Title: Structural insights into choline translocation through CHT.

5. Antonio Martínez Ruiz, Hospital Universitario Santa Cristina, Instituto de Investigación Sanitaria Princesa.
   Title: Sodium regulates mitochondrial electron transport chain by altering inner membrane fluidity.

11:00-11:30

Coffee break (at the same halls of the first and second floors of the classrooms building where posters will be posted)

11:30-12:30

Plenary Lecture (III), Main Hall Alfredo Pérez Rubalcaba.

Chair: Bárbara Olmeda, Associate Professor, Department of Biochemistry and Molecular Biology, Faculty of Biology, Complutense University, Madrid.

Lecturer: Aitziber López Cortajarena, Professor, Biomolecular Nanotechnology Laboratory, CICbiomaGUNE, Parque Científico y Tecnológico de Gipuzkoa, Donostia/San Sebastián.

Title: From Molecular Design to Functional Materials: Engineering Protein Assemblies for Biomedical and Technological Applications.

12:30-13:00

Short Sponsor presentation, Ana María Lajusticia Hall.

Paralab Bio
Andrea Zapater, PhD. Product Specialist BIO

Title: New techniques in biophysics

13:00-14:30

Lunch at the self-service cafeteria of the Faculty of Chemical Sciences.

14:30-16:30

Poster session II (at the halls of the first and second floors of the classrooms building).

16:00-16:30

Coffee break (at the same halls of the first and second floors of the classrooms building where posters will be posted).

16:30-18:30

SBE Awards

16:30 h. SBE awards. Chair: José María Valpuesta

16:35 h. SBE under 33 Hawk Biosystems award: Roger Castell-Graells.

16:55 h. SBE «E. Pérez Payá» under 40 Prospera BCN Peptides award: Edurne Rujas.

17:15 h. SBE «Manuel Rico» Bruker award: José María Carazo.

17:45 h. Awards ceremony for the best theses in biophysics (year 2024).

17:50 h. New SBE honorary members ceremony

17:55 h. Marta Bruix. Introductory words by Douglas Laurents

18:00 h. Carlos Gómez Moreno. Introductory words by Nunilo Cremades.

18:05 h. José López Carrascosa. Introductory words by José M. Valpuesta.

18:30-20:00

SBE General Assembly.

20:30

Social Dinner at the Cafeteria of the Faculty of Chemical Sciences

9:30-10:30

Plenary Lecture (IV), Main Hall Alfredo Pérez Rubalcaba.

Chair: José María Valpuesta, President of the SBE, Professor, Structure and function of molecular chaperones Group, Centro Nacional de Biotecnología (CNB), CSIC, Madrid.

Lecturer: Carlos Bustamante, Professor of Molecular and Cell Biology, Professor of Physics, Professor of Chemistry, University of California, Berkeley, Howard Hughes Medical Institute Investigator, USA.

Title: FACT promotes efficient Pol II transcription by modulating the topographic features of the nucleosomal barrier.

10:30-11:00

Coffee break (at the same halls of the first and second floors of the classrooms building where posters will be posted)

11:00-13:00

Two parallel sessions.

Session 9

(Classroom QC13): Advanced bioimaging.

Chair: Oriol Gallego, Professor, Department of Medicine and Life Sciences, Universitat Pompeu Fabra (UPF), Barcelona.

Two talks of about 25-30 min:

Antonio Martínez-Sánchez, Tenure-track Associate Professor, Information and Communications Engineering, Computer Sciences, the University of Murcia.

Title: Cryo-electron tomography for comprehensive visual protemics.

Arrate Muñoz, Professor, Carlos III University (UC3M), Madrid.

Title: From pixels to insights: Deep learning tools for interpretable bioimage analysis.

Four short talks of 10 minutes long:

1. Carlo Manzo, Universitat de Vic.
   Title: Graph Neural Networks for Localization Microscopy: Toward Physics-Informed Learning.

2. Pedro J de Pablo, Universidad Autónoma de Madrid.
   Title: Physical Virology with atomic force and fluorescence microscopies: seeing and touching viruses.

3. Laura Betancur, UPF.
   Title: Resolving the dynamic architecture of protein networks in situ.

4. Iago Grobas, i2sysbio, CSIC-UV.
   Title: FtsZ predicts bending events that modulate Min patterning and division in E. coli filaments.

Session 10

(Classroom QC23): Systems biophysics.

Chairs: Javier Buceta, Research Group Leader, Institute for Integrative Systems Biology, I2SysBio CSIC-UV.

Félix Ritort, Professor, Condensed Matter Physics, The Small Biosystems Lab, University of Barcelona.

Two talks of about 25-30 min:

Saúl Ares, Staff Scientist, Systems Biology, Centro Nacional de Biotecnología, CSIC, Madrid.

Title: Feedback control of organ size precision in the Drosophila eye.

Pilar Guerrero, Departamento de Matemáticas and Grupo Interdisciplinar de Sistemas Complejos (GISC), Universidad Carlos III de Madrid.

Title: Modelling the Influence of Loss of E-Catherin and Stroma Attachment in Cancer Cell Invasion.

Five short talks of 10 minutes long:

1. Sergio Alonso, Universitat Politècnica de Catalunya.
   Title: Modeling Cell Polarization and Locomotion: Insights from Dictyostelium discoideum Motility.

2. Adolfo Alsina, Universidad Rey Juan Carlos.
   Title: Model-based inference of cell cycle dynamics captures alterations of the DNA replication programme.

3. Josep Mercadal, Max Planck Institute for Plant Breeding Research (MPIPZ).
   Title: The mechanistic basis of trichome patterns and their diversity.

4. David Míguez, Universidad Autónoma de Madrid.
   Title: Compartmentalization as a physical mechanism of biological regulation.

5. Gabriel Piedrafita, Universidad Complutense de Madrid.
   Title: A simple predictive cell-fate model of epithelial clone dynamics.

Two short flash talks of 3 minutes long:

1. Pablo Domínguez-García, Universidad Nacional de Educación a Distancia (UNED).
   Title: High-frequency micro-viscoelasticity of fibrin, actin and myosin aqueous suspensions by using optical trapping interferometry.

2. Jorge Tabanera Bravo, Max-Planck-Institute for Multidisciplinary Sciences.
   Title: Multiple Pareto-optimal solutions of the dissipation-adaptation trade-off.

13:00-14:00

Plenary Lecture (V), Main Hall Alfredo Pérez Rubalcaba.

Chair: Jesús Pérez-Gil, Professor, Department of Biochemistry and Molecular Biology, Faculty of Biology, Complutense University, Madrid.

Lecturer: Alicia Alonso/Felix M. Goñi, Basque Country University. A tribute to their retirement

Title: Biofísica al alimón/Biophysics together.

14:00-14:30

Awards & Concluding remarks